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The Giant cell is a giant, three-eyed cell with four fins found in levels 28, 29, and briefly, 30 In Spore Origins. The giant cell will deal nine damage to the player if touched. On level 29, the player is required to trick manteee-like creatures into charging into it; which requires three charges to defeat it. When defeated, the cell will explode into tons of smaller cells, which therefore, are the only food found in the level.

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